Bank of America Merrill Lynch (BAML) has announced it will be closing its Croydon data centre next year.
The bank told staff they will be moving out of Galaxy House in Cherry Orchard Road and relocating to other offices in Canary Wharf and Bromley.
The centre which is close to East Croydon station, will close during the first quarter of 2013.
The news comes six months after Nestle confirmed it would be leaving Croydon after 47 years.
The food giant announced in January it would be moving its UK base from St George's House in Park Lane, to new offices in Crawley.
A spokesman for Bank of America Merrill Lynch said: "The data centre located in Croydon is scheduled to close in Q1 2013.
"Croydon was originally set up as a data centre facility and as part of a regular review of our technology and support infrastructure, it was decided to consolidate this site in order to reduce the overall number of data centres we use globally.
"The consolidation and closure of the data centre in Croydon will allow us to modernise and simplify our IT infrastructure to better meet the needs of our clients."
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here